Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation
نویسندگان
چکیده
منابع مشابه
Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: convergences and divergences.
The role of nitric oxide in several signalling routes has been clearly established. In recent years increasing attention has been paid to its ability to produce covalent protein post-translational modifications in conjunction with other reactive oxygen and nitrogen species. Among these, the modification of cysteine residues has been shown to be of particular importance due to the functional rel...
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Mitochondria play an essential role in nitric oxide (NO) signal transduction in plants. Using the biotin-switch method in conjunction with nano-liquid chromatography and mass spectrometry, we identified 11 candidate proteins that were S-nitrosylated and/or glutathionylated in mitochondria of Arabidopsis (Arabidopsis thaliana) leaves. These included glycine decarboxylase complex (GDC), a key enz...
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Neurodegenerative diseases involve the progressive loss of neurons, and a pathological hallmark is the presence of abnormal inclusions containing misfolded proteins. Although the precise molecular mechanisms triggering neurodegeneration remain unclear, endoplasmic reticulum (ER) stress, elevated oxidative and nitrosative stress, and protein misfolding are important features in pathogenesis. Pro...
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The NADPH oxidase homolog dual oxidase 1 (DUOX1) plays an important role in innate airway epithelial responses to infection or injury, but the precise molecular mechanisms are incompletely understood and the cellular redox-sensitive targets for DUOX1-derived H2O2 have not been identified. The aim of the present study was to survey the involvement of DUOX1 in cellular redox signaling by protein ...
متن کاملCurrent Methods for the Identification of Sites of S-Glutathionylation and S-Nitrosylation in Proteins
Chemical modification of protein thiols has profound effects on the structure and catalytic activity of proteins. These post-translational modifications are often transient in nature, and therefore characterization of them can be elusive, especially in the case of S-nitrosothiols. Many of the methods discussed here involve a trapping mechanism where the modified thiol is selectively reduced and...
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ژورنال
عنوان ژورنال: Molecules
سال: 2021
ISSN: 1420-3049
DOI: 10.3390/molecules26020435